A bottle of NatureSpan® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

The backside of a bottle of NatureSpan® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

The supplement facts of NatureSpan® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

Cellular Energy, Anti-Aging & Brain Support

NAD+ L-Ergothioneine + PQQ

$59.99

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

Key Benefits

✔ Elevates NAD+ to power cellular energy and performance*
✔ Promotes mitochondrial biogenesis, repair, and resilience*
✔ Provides advanced antioxidant defense for healthy aging*
✔ Supports cognitive clarity, focus, and nerve vitality*
✔ Nourishes skin health and overall daily wellness*

NR-CL NAD+ Boost Dr.Ergo® Ergothioneine PureQQ® PQQ Produced in USA

The NatureSpan® Difference

🛡️ Patented Triple Synergy

NR-CL boosts NAD+ for ATP production, PureQQ® PQQ promotes new mitochondria, and Dr.Ergo® ergothioneine shields cells with potent antioxidant protection.

🛡️ Clinically Aligned Dosing

300 mg NR-CL, 25 mg Dr.Ergo®, and 10 mg PureQQ® deliver effective, complementary support for energy, cognition, and skin health.

🛡️ Cellular Protection at the Source

Targets oxidative stress and supports Nrf2 pathways to help maintain youthful cell function and recovery.

🛡️ Clean, Everyday Formula

Vegan capsules, non-GMO excipients, and evidence-led actives designed for daily use.

Supplement Facts

NatureSpan® NAD+ L-Ergothioneine + PQQ

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Nicotinamide Riboside Chloride (NR-CL)

300 mg

†

L-Ergothioneine

(as Dr. Ergo®)

25 mg

†

Pyrroloquinoline Quinone Disodium Salt (PQQ)

(as PureQQ®)

10 mg

†

† Daily Value not established.

Other Ingredients: Hypromellose (vegetable capsule), microcrystalline cellulose, and magnesium stearate. Non-GMO, Gluten-Free, Soy-Free, Vegetarian

PureQQ® is a registered trademark of HOWTIAN LLC, protected under one or more of the following patents: US 8,088,422 B2, ZL 201210452297.6, ZL200810033088.1.

Dr. Ergo® is a registered trademark of Anti-aging Ingredients LLC and is protected by patent: ZL 2023 8 0010573.X.

Usage & Safety

Who It’s For: Ideal for individuals experiencing low energy, seeking anti-aging and beauty support, improving skin health, boosting metabolism, enhancing brain and heart function, and maintaining overall vitality.*

Who Should Avoid It: Not recommended for individuals taking medications without consulting a physician. Pregnant or nursing women should seek medical advice before use.*

Dosage: Take 2 capsules daily with a meal.*

Bottle Supply: 30 capsules (1-month supply).*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility; free from GMOs, gluten, soy, and the eight major allergens for safety and purity.*

Scientific References

Apparoo Y, Phan CW, Kuppusamy UR, Sabaratnam V. Ergothioneine and its prospects as an anti-ageing compound. Exp Gerontol. 2022 Dec;170:111982. doi: 10.1016/j.exger.2022.111982. PMID: 36244584.
Hseu YC, Lo HW, Korivi M, Tsai YC, Tang MJ, Yang HL. Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated human keratinocytes. Free Radic Biol Med. 2015 Sep;86:102-17. doi: 10.1016/j.freeradbiomed.2015.05.026. Epub 2015 May 27. PMID: 26021820.
Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. PMID: 34843394.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. PMID: 22682224; PMCID: PMC3616313.
Tamakoshi M, Suzuki T, Nishihara E, Nakamura S, Ikemoto K. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. Food Funct. 2023 Mar 6;14(5):2496-2501. doi: 10.1039/d2fo01515c. PMID: 36807425.

Cellular Energy, Anti-Aging & Brain Support NAD+ L-Ergothioneine + PQQ

$59.99

Fast Delivery for Your Family

We make sure wellness reaches your home without delay. Read more about our shipping policy

100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Fuel NAD+, Renew Mitochondria, Defend Skin

NR-CL, Dr.Ergo® ergothioneine, and PureQQ® PQQ elevate NAD+, spark mitochondrial biogenesis, and shield cells from oxidative stress. Clinically aligned doses support daily energy, cognitive clarity, and resilient, healthy skin.

NR-Driven NAD+ Energy

Raises cellular NAD+ to power mitochondrial ATP production, supporting daily stamina and efficient recovery.

Dr.Ergo® Skin Defense

Ergothioneine targets mitochondrial oxidative stress via Nrf2 signaling to maintain resilient, healthy skin.

PureQQ® Mitochondrial Renewal

PQQ stimulates mitochondrial biogenesis to enhance energy metabolism and whole-body cellular resilience.

Synergy for Healthy Aging

NR-CL, Dr.Ergo®, and PQQ work together to deliver coordinated energy, antioxidant protection, and repair for cognitive clarity and long-term wellness.

FAQ

What does this supplement actually do?

This formula is designed to recharge your cells from the inside out. NAD+ boosts energy and repair, PQQ helps create new mitochondria for long-term vitality, and L-Ergothioneine provides powerful antioxidant protection to keep your cells, skin, and brain healthy.

Why include all three: NAD+, PQQ, and L-Ergothioneine?

Each ingredient plays a different but complementary role. NAD+ supports energy and repair, PQQ promotes the growth of new mitochondria, and L-Ergothioneine helps shield cells from stress and aging. Together, they create a synergy that’s greater than any single ingredient alone.

Who is this product best suited for?

It’s a great fit for adults who want to fight fatigue, support healthy aging, sharpen mental focus, or give their skin and cells a resilience boost. It’s especially popular with people looking for all-in-one energy and anti-aging support.

How long does it take to notice benefits?

Some users feel more energy and focus within a few weeks, while deeper benefits like improved skin, cognitive support, and cellular renewal often build up with consistent use over time. Think of it as investing in your long-term vitality.