A bottle of Nature Span® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

The backside of a bottle of Nature Span® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

The supplement facts of Nature Span® NAD+ PQQ L-Ergothioneine supplement with white and blue label.

Cellular Energy, Anti-Aging & Brain Support

NAD+ L-Ergothioneine + PQQ

$149.99

4.6

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

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Key Benefits

✔ Supports natural NAD+ levels to power daily cellular energy
✔ Promotes mitochondrial renewal, repair, and resilience
✔ Provides advanced antioxidant protection for healthy aging
✔ Supports focus, mental clarity, and nerve vitality
✔ Contributes to skin wellness and overall vitality

NR-CL 300 mg Dr.Ergo® Ergothioneine PureQQ® PQQ Produced in Canada

The Nature Span® Difference

🧬 Patented Triple Synergy

NR-CL supports NAD+ generation for energy production, PureQQ® PQQ promotes new mitochondria, and Dr.Ergo® ergothioneine delivers potent antioxidant protection for cellular health.

🧬 Clinically Balanced Dosing

300 mg NR-CL, 25 mg Dr.Ergo®, and 10 mg PureQQ® provide complementary support for energy, cognitive performance, and skin wellness.

🧬 Cellular Protection from Within

Targets oxidative stress and supports Nrf2 pathways to help maintain youthful cell performance and recovery.

🧬 Clean, Everyday Formula

Vegan, allergen-conscious capsules formulated for consistent daily use.

Supplement Facts

Nature Span® NAD+ L-Ergothioneine + PQQ

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Nicotinamide Riboside Chloride (NR-CL)

300 mg

†

L-Ergothioneine

(as Dr. Ergo®)

25 mg

†

Pyrroloquinoline Quinone Disodium Salt (PQQ)

(as PureQQ®)

10 mg

†

† Daily Value not established.

Other Ingredients: Hypromellose (vegetable capsule), microcrystalline cellulose, and magnesium stearate. Non-GMO, Gluten-Free, Soy-Free, Vegetarian

PureQQ® is a registered trademark of HOWTIAN LLC, protected under one or more of the following patents: US 8,088,422 B2, ZL 201210452297.6, ZL200810033088.1.

Dr. Ergo® is a registered trademark of Anti-aging Ingredients LLC and is protected by patent: ZL 2023 8 0010573.X.

Usage & Safety

Who It’s For: Ideal for individuals experiencing low energy, seeking anti-aging and beauty support, improving skin health, boosting metabolism, enhancing brain and heart function, and maintaining overall vitality.*

Who Should Avoid It: Not recommended for individuals taking medications without consulting a physician. Pregnant or nursing women should seek medical advice before use.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 30 capsules (1-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility; free from gluten, soy, and the eight major allergens for safety and purity.*

Scientific References

Apparoo Y, Phan CW, Kuppusamy UR, Sabaratnam V. Ergothioneine and its prospects as an anti-ageing compound. Exp Gerontol. 2022 Dec;170:111982. doi: 10.1016/j.exger.2022.111982. PMID: 36244584.
Hseu YC, Lo HW, Korivi M, Tsai YC, Tang MJ, Yang HL. Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated human keratinocytes. Free Radic Biol Med. 2015 Sep;86:102-17. doi: 10.1016/j.freeradbiomed.2015.05.026. Epub 2015 May 27. PMID: 26021820.
Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021 Nov 30;144(22):1795-1817. doi: 10.1161/CIRCULATIONAHA.121.056589. Epub 2021 Nov 29. PMID: 34843394.
Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. doi: 10.1016/j.cmet.2012.04.022. PMID: 22682224; PMCID: PMC3616313.
Tamakoshi M, Suzuki T, Nishihara E, Nakamura S, Ikemoto K. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. Food Funct. 2023 Mar 6;14(5):2496-2501. doi: 10.1039/d2fo01515c. PMID: 36807425.

Cellular Energy, Anti-Aging & Brain Support NAD+ L-Ergothioneine + PQQ

$149.99

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Recharge NAD+, Renew Mitochondria, Protect Cells

Nature Span® combines NR-CL, Dr.Ergo® ergothioneine, and PureQQ® PQQ to enhance NAD+ levels, promote mitochondrial renewal, and defend cells from oxidative stress. Clinically balanced doses help sustain energy, focus, and skin resilience for everyday wellness.

NAD+ Energy & Cellular Power

Supports cellular NAD+ to enhance mitochondrial ATP production, promoting steady energy, stamina, and efficient recovery.

Dr.Ergo® Antioxidant Protection

L-Ergothioneine supports the body’s natural antioxidant defenses and Nrf2 signaling, helping maintain healthy, resilient cells and skin.

PureQQ® Mitochondrial Support

PQQ promotes mitochondrial biogenesis to strengthen metabolism, energy production, and long-term cellular function.

Triple Synergy for Longevity

NR-CL, Dr.Ergo®, and PQQ work together to sustain energy, protect against oxidative stress, and support overall cognitive and skin vitality.

FAQ

What does this supplement do?

It supports your body’s natural energy and repair systems. NAD+ helps produce cellular energy, PQQ promotes mitochondrial renewal, and L-Ergothioneine provides strong antioxidant protection for cells, skin, and brain health.

Why combine NAD+, PQQ, and L-Ergothioneine?

Each has a unique role—NAD+ fuels energy, PQQ supports new mitochondria, and L-Ergothioneine helps protect cells from oxidative stress. Together, they form a complete system for daily cellular wellness.

Who can benefit most from this formula?

Ideal for adults seeking support for energy, focus, and healthy aging. It’s also suitable for those who want to promote resilience in skin, nerve, and overall cellular health.

When can I expect to notice results?

Some users feel more energetic and clear-headed within weeks, while benefits like improved skin tone, cellular renewal, and vitality develop with consistent, long-term use.