A box of NatureSpan® Tri-Layer Tablets Activated Homocysteine with red and white color scheme.

Activated Homocysteine

$59.99

Quantity:

Bottle Size: 60 Veggie Capsules

60 Veggie Capsules

Key Benefits

✔ Supports healthy homocysteine metabolism for heart and vascular wellness*
✔ Promotes methylation to fuel energy, mood, and cognitive clarity*
✔ Helps maintain liver fat and lipid balance with betaine (TMG)*
✔ Nourishes nerve health and red blood cell formation with active B-vitamins*
✔ Aids prenatal wellness and DNA synthesis with bioactive 5-MTHF*

Quatrefolic® 5-MTHF Methyl B6 & B12 TMG Support Produced in USA

The NatureSpan® Difference

🛡️ Quatrefolic® 5-MTHF

Bioactive folate bypasses genetic conversion steps to directly support methylation and effective homocysteine recycling.*

🛡️ Methylated & Coenzyme B’s

Methylcobalamin (B12) and pyridoxal-5-phosphate (B6) arrive body-ready for superior absorption, utilization, and neurological support.*

🛡️ TMG (Betaine) Synergy

Natural methyl donor complements folate/B12 pathways, reinforcing balanced homocysteine and liver lipid metabolism.*

🛡️ Clinical-Dose, Clean Label

Thoughtful, evidence-led dosing in vegan capsules; non-GMO, gluten-free, and soy-free for everyday confidence.*

Supplement Facts

NatureSpan® Activated Homocysteine

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 60

Amount Per Serving

%DV

Vitamin B6

(as pyridoxal 5-phosphate)

50 mg

2,941%

Folate

(as Quatrefolic® [6S]-5-methyltetrahydrofolic acid equivalent to 1.6 mg of [6S]-5-methyltetrahydrofolic acid, glucosamine salt)

800 mcg DFE

200%

Vitamin B12

(methylcobalamin)

500 mcg

20,833%

TMG

(trimethylglycine from betaine anhydrous)

500 mg

†

† Daily Value not established.

Other Ingredients: Hypromellose (vegetable capsule), rice flour, magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis S.p.A., U.S. patent no. 7,947,622.

Usage & Safety

Who It’s For: Ideal for individuals looking to support cardiovascular and cerebrovascular health, maintain healthy cholesterol and homocysteine levels, protect liver function, enhance neurological and cognitive health, and promote overall vitality.*

Who Should Avoid It: Not recommended for individuals taking medications or those with medical conditions without consulting a physician.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 60 capsules (2-month supply).*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility; free from the eight major common allergens for safety and purity.*

Scientific References

Friso S, Lotto V, Corrocher R, Choi SW. Vitamin B6 and cardiovascular disease. Subcell Biochem. 2012;56:265-90.
Cui Q, Zhu X, Guan G, Hui R, Zhu L, Wang J, Zhao J. Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults. Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1225-1234.
Kliueva NN, Kalashnikova NM, Okunevich IV, Sapronov NS. [Hypolipidemic activity of trimethylglycine]. Eksp Klin Farmakol. 2012;75(1):16-8. Russian.
Miraglia N, Dehay E. Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate. Altern Ther Health Med. 2022 May;28(4):12-17. PMID: 35653630.
Ryan-Harshman M, Aldoori W. Vitamin B12 and health. Can Fam Physician. 2008 Apr;54(4):536-41. PMID: 18411381; PMCID: PMC2294088.

Cardiovascular & Brain Health Activated Homocysteine

$59.99

Fast Delivery for Your Family

We make sure wellness reaches your home without delay. Read more about our shipping policy

100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Activated Homocysteine & Methylation Support

Quatrefolic® 5-MTHF, methylcobalamin B12, and P5P B6 combine with betaine (TMG) to support homocysteine metabolism, cardiovascular health, and cognitive function—delivered in clean, vegan capsules.

Bioactive Quatrefolic® Folate

Utilizes research-backed 5-MTHF to enter the methylation cycle directly. Supports homocysteine conversion, prenatal wellness, and DNA synthesis for foundational cellular health.

Methyl B12 + P5P B6

Provides body-ready forms that power neurotransmitter production and red blood cell formation. Designed to optimize absorption and effective homocysteine management.

Betaine-Driven Synergy

TMG donates methyl groups that complement folate/B12 activity. Together they reinforce balanced homocysteine, lipid metabolism, and liver function for whole-body benefits.

Clean, Consistent Formulation

Vegan capsules with transparent dosing and quality standards. Non-GMO, gluten-free, and soy-free to fit modern lifestyles without compromising efficacy

FAQ

What does “Activated Homocysteine” mean?

This formula is designed to help keep homocysteine levels in a healthy range by using bioactive forms of B-vitamins and other supportive nutrients. “Activated” means your body can absorb and use the nutrients right away, without needing extra conversion.

Why are healthy homocysteine levels important?

Balanced homocysteine is linked to cardiovascular, brain, and overall cellular health. Elevated levels may put stress on the heart, blood vessels, and nerves, so supporting a healthy balance helps protect long-term wellness.

Who might benefit from taking Activated Homocysteine?

It’s especially helpful for adults interested in supporting heart health, cognitive function, and energy metabolism. It may also benefit those who want extra nutritional support for healthy aging and circulation.

How is this product different from a standard B-complex?

Unlike standard formulas, this supplement uses advanced, bioavailable forms such as methylated B12 and folate. That means better absorption, quicker action, and more reliable support for managing homocysteine levels.