A bottle of NatureSpan® Folate 5-Methyltetrahydrofolic Acid 800 mcg supplement, white and orange label with product information.

Folate 5-Methyltetrahydrofolic Acid 800 mcg

Q: How is this folate different from regular folic acid?

Unlike synthetic folic acid, this supplement provides 5-Methyltetrahydrofolic Acid (5-MTHF) , the active form of folate your body can use right away. That means no conversion needed, making it more reliable for supporting energy, mood, and overall wellness.

Q: Why is folate important for daily health?

Folate plays a central role in cell growth, red blood cell formation, and homocysteine metabolism . It supports cardiovascular health, brain function, and even helps maintain a healthy mood by aiding neurotransmitter production.

$49.99

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

Key Benefits

✔ Supports prenatal neural tube development*
✔ Maintains healthy homocysteine levels & heart health*
✔ Promotes red blood cell formation & energy metabolism*
✔ Supports methylation & efficient folate utilization (MTHFR)*
✔ Aids healthy cell division & DNA synthesis*

High-Strength 800 mcg Bioactive 5-MTHF MTHFR-Friendly Produced in USA

The NatureSpan® Difference

🛡️ Quatrefolic® 4th-Gen Active Folate

Bioactive (6S)-5-MTHF glucosamine salt bypasses conversion for superior uptake and consistent blood folate levels.

🛡️ Methylation & Homocysteine Support

Delivers the body’s usable folate to power methylation cycles, balance homocysteine, and support cardiovascular wellness.

🛡️ Gentle & Highly Bioavailable

Active folate is well tolerated and effective even for common MTHFR variants, supporting reliable daily use.

🛡️ Verified Purity & Potency

Transparent dosing at 800 mcg DFE per capsule; vegan, non-GMO, and produced to rigorous GMP/NSF standards.

Supplement Facts

NatureSpan® Folate 5-Methyltetrahydrofolic Acid 400 mcg

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Folate

(as Quatrefolic® [glucosamine salt of (6S)-5-methyltetrahydrofolic])

800 mcg DFE

200%

Other Ingredients: Rice flour, hypromellose (vegetable capsule), magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis by Lesaffre.

Quatrefolic® folate is the result of Gnosis by Lesaffre's research on folate derivatives and is the only company whose three folate products have been granted GRAS (Generally Recognized As Safe) status.

In 2011, Quatrefolic® received the Nutritional Food Business Technology Award (NBT), being recognized as "the most effective strategic product R&D."

Quatrefolic® won the NutrAward in 2012, being rated as "the best and latest in nutrition."

Quatrefolic® patent number: US 7,947,662 B2

Usage & Safety

Who It’s For: Adults seeking higher-strength folate support for methylation, homocysteine metabolism, cardiovascular function, cellular energy, and prenatal/nervous system health. Especially suitable for those who prefer the active form of folate (5-MTHF), including individuals with reduced ability to convert folic acid due to genetic variations (e.g., MTHFR).*

Who Should Avoid It: Not recommended without physician guidance if you are pregnant/nursing, under 18, have a medical condition, or take medications—especially antifolate therapies (e.g., methotrexate or certain chemotherapeutics), anticonvulsants, or if you have vitamin B12 deficiency (high folate may mask B12 deficiency). Discontinue and consult a professional if you experience adverse effects.*

Dosage: Take 1 capsule daily with a meal, or as directed by your healthcare professional. Each capsule provides 800 mcg of 5-methyltetrahydrofolate (5-MTHF).*

Bottle Supply: 60 veggie capsules (60-day supply at 1 capsule daily).*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility for quality and safety.*

Scientific References

Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5-methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:312-319. PMID: 32868164.
Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Am J Med Sci. 2017 Oct;354(4):379-387. PMID: 29078842.
Sicińska E, Brzozowska A, Roszkowski W, Finglas PM. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Int J Food Sci Nutr. 2018 Feb;69(1):64-73. PMID: 28460586.
Norsworthy B, Skeaff CM, Adank C, Green TJ. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004 Mar;58(3):548-54. PMID: 14985695.

Heart & Prenatal Health Folate 5-Methyltetrahydrofolic Acid 800 mcg

$49.99

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Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Bioactive Folate for Every Body

Quatrefolic® 5-MTHF (800 mcg DFE) provides ready-to-use folate to support methylation, homocysteine balance, prenatal neural tube development, and red blood cell formation. Highly bioavailable, vegan, and gentle—even with MTHFR variants.

Quatrefolic® Active Folate

Fourth-generation, bioactive 5-MTHF skips conversion steps for superior absorption and reliability. Consistently raises blood folate to support everyday wellness and prenatal needs.

Methylation & Heart Support

Provides the usable folate required for methylation pathways. Helps maintain healthy homocysteine, supporting cardiovascular health and balanced neurotransmitter production.

Prenatal & RBC Benefits

Backs healthy neural tube development before and during early pregnancy. Supports red blood cell formation to help sustain oxygen transport and daily energy.

Gentle, Clean & Consistent

Vegan capsules with transparent 800 mcg DFE dosing. Non-GMO and allergen-conscious, produced under GMP/NSF standards for purity, potency, and trust.

FAQ

How is this folate different from regular folic acid?

Unlike synthetic folic acid, this supplement provides 5-Methyltetrahydrofolic Acid (5-MTHF), the active form of folate your body can use right away. That means no conversion needed, making it more reliable for supporting energy, mood, and overall wellness.

Why is folate important for daily health?

Folate plays a central role in cell growth, red blood cell formation, and homocysteine metabolism. It supports cardiovascular health, brain function, and even helps maintain a healthy mood by aiding neurotransmitter production.

Is this supplement suitable for women planning pregnancy?

Yes. Folate is one of the most recommended nutrients for women before and during pregnancy because it helps support healthy fetal development and reduces the risk of neural tube defects. Always check with your healthcare provider before starting any new supplement.

Can this product benefit men and older adults too?

Absolutely. Beyond pregnancy support, 5-MTHF is valuable for cardiovascular health, cognitive function, and energy metabolism, making it beneficial for men, seniors, and anyone looking to support long-term wellness.