The bottle of Nature Span® Folate 5-Methyltetrahydrofolic Acid 800 mcg supplements, with a white label and orange and white branding

The backside of Nature Span® Folate 5-Methyltetrahydrofolic Acid 800 mcg supplements, with a white label and orange and white branding.

The supplement facts of Nature Span® Folate 5-Methyltetrahydrofolic Acid 800 mcg supplements, with a white label and orange and white branding.

Folate [6S]-5-Methyltetrahydrofolic Acid 800 mcg

$49.99

4.3

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

Key Benefits

✔ Supports healthy folate status and overall wellness
✔ Helps maintain normal homocysteine levels & metabolic balance
✔ Contributes to red blood cell formation & natural energy production
✔ Provides active folate for methylation & nutrient utilization
✔ Aids normal cell division & DNA formation

Quatrefolic® (6S)-5-MTHF Methylation Support Vegan Capsules Produced in USA

The Nature Span® Difference

🧬 Quatrefolic® 4th-Gen Active Folate

Bioactive (6S)-5-MTHF glucosamine salt designed for consistent absorption and dependable folate levels to support daily nutrition.

🧬 Methylation & Nutritional Balance

Supplies the body with active folate that contributes to one-carbon metabolism, helping maintain normal homocysteine levels and overall metabolic wellness.

🧬 Gentle & Highly Bioavailable

Active folate form designed for steady daily use and suitable for varied nutritional needs.

🧬 Verified Purity & Potency

Transparent dosing at 800 mcg DFE per capsule; vegan and produced to rigorous GMP/NSF standards.

Supplement Facts

Nature Span® Folate 5-Methyltetrahydrofolic Acid 800 mcg

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Folate

(as Quatrefolic® [glucosamine salt of (6S)-5-methyltetrahydrofolic])

800 mcg DFE

200%

Other Ingredients: Rice flour, hypromellose (vegetable capsule), magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis by Lesaffre.

Quatrefolic® folate is the result of Gnosis by Lesaffre's research on folate derivatives and is the only company whose three folate products have been granted GRAS (Generally Recognized As Safe) status.

In 2011, Quatrefolic® received the Nutritional Food Business Technology Award (NBT), being recognized as "the most effective strategic product R&D."

Quatrefolic® won the NutrAward in 2012, being rated as "the best and latest in nutrition."

Quatrefolic® patent number: US 7,947,662 B2

Usage & Safety

Who It’s For: Ideal for women planning for pregnancy, expectant mothers, individuals with high homocysteine levels, and adults seeking to support heart health, DNA synthesis, and overall cellular vitality.*

Who Should Avoid It: Not recommended for individuals taking medications or with health conditions without consulting a physician.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 30 capsules (1-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in FDA, NSF-certified GMP facility. Allergen-free, Vegan, and formulated with Quatrefolic® for superior absorption and purity.*

Scientific References

Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5-methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:312-319. PMID: 32868164.
Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Am J Med Sci. 2017 Oct;354(4):379-387. PMID: 29078842.
Sicińska E, Brzozowska A, Roszkowski W, Finglas PM. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Int J Food Sci Nutr. 2018 Feb;69(1):64-73. PMID: 28460586.
Norsworthy B, Skeaff CM, Adank C, Green TJ. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004 Mar;58(3):548-54. PMID: 14985695.

Heart & Prenatal Health Folate [6S]-5-Methyltetrahydrofolic Acid 800 mcg

$49.99

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100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Bioactive Folate for Everyday Wellness

Quatrefolic® (6S)-5-MTHF (800 mcg DFE) provides ready-to-use folate to support balanced metabolism, homocysteine maintenance, and red blood cell formation. Highly bioavailable, vegan and gentle for consistent daily use.

Quatrefolic® Active Folate

Fourth-generation, bioactive (6S)-5-MTHF skips unnecessary conversion steps for superior absorption and reliability. Supports consistent folate status for daily wellness across life stages.

Methylation & Nutritional Support

Provides active folate that contributes to natural methylation processes. Helps maintain normal homocysteine balance and supports overall metabolic and energy health.

Comprehensive Folate Benefits

Contributes to normal cell growth and red blood cell formation, supporting nutrient utilization and steady energy for everyday vitality.

Gentle, Clean & Consistent

Vegan capsules with transparent 800 mcg DFE dosing. Allergen-conscious, produced under GMP/NSF standards for purity, potency, and trust.

FAQ

How is this folate different from regular folic acid?

Unlike synthetic folic acid, this supplement provides 5-Methyltetrahydrofolic Acid (5-MTHF), the active form of folate that’s readily available for your body to use. That means dependable absorption and consistent nutritional support for energy and overall wellness.

Why is folate important for daily health?

Folate plays a key role in cellular processes, including red blood cell formation and homocysteine metabolism. It contributes to balanced energy, cellular renewal, and overall wellbeing.

Is this supplement suitable for daily nutritional routines?

Yes. Folate is an essential B vitamin important for maintaining healthy folate levels through different life stages. It’s suitable for adults seeking balanced daily nutritional support as part of a healthy lifestyle.

Can this product benefit both men and women?

Absolutely. Folate contributes to metabolic balance, energy support, and overall wellness—making it beneficial for adults of all ages who value daily nutritional maintenance.

I’ve been taking this active folate for a couple of weeks and already feel more energetic and balanced. The capsules are easy to swallow and gentle on my stomach. Really pleased so far!

Subtle But Real Benefits

Took a while to see a difference (around 3 weeks), but now I feel steadier energy and better digestion. No side effects for me. The label is clear and dosage simple. Good supplement overall.

Noticeable Energy Boost and Peace of Mind

I’ve been taking this Folate 800 for about 6 weeks now. I feel more energetic, and my bloodwork shows better folate levels. The Quatrefolic® active form seems to agree with me (I have the MTHFR variant). Capsules are easy to swallow and no odd aftertaste. Highly recommended.

Works Well, A Bit Pricey

Good product. After starting it I noticed improved mood and less fatigue. The price is a bit on the high side, but given the quality (vegan, non-GMO, active folate) it seems worth it. Will repurchase.

Best Folate I’ve Tried

Absolutely love this folate formulation. I’ve tried many folic acid supplements before, but this active 5-MTHF version seems more reliable. I’m pregnant and wanted a high quality folate — this gives me peace of mind. Excellent purity and potency.

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