A bottle of NatureSpan® Folate 5-Methyltetrahydrofolic Acid 400 mcg supplements, with a white label and orange and white branding.

Folate 5-Methyltetrahydrofolic Acid 400 mcg

Q: What makes 400 mcg of folate a good choice?

The 400 mcg strength is often recommended for daily maintenance of folate levels. It’s a gentle yet effective dose that supports energy, mood balance, and healthy cell function without being overwhelming.

Q: How does this form of folate compare to folic acid in food or other supplements?

This supplement uses 5-Methyltetrahydrofolic Acid (5-MTHF) — the biologically active form of folate. Unlike folic acid, it’s ready for your body to absorb and use right away, which is especially helpful for people who may not efficiently convert folic acid.

Q: Can I take this supplement long-term?

Yes. Folate is a water-soluble B vitamin , which means your body uses what it needs and naturally eliminates the rest. Taken as directed, it’s safe for daily use to help support lifelong wellness.

$49.99

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

Key Benefits

✔ Supports prenatal neural tube development*
✔ Maintains healthy homocysteine & cardiovascular function*
✔ Promotes red blood cell formation & energy metabolism*
✔ Supports methylation & neurotransmitter pathways*
✔ Delivers gentle, foundational daily folate support*

Quatrefolic® 5-MTHF Methylation Ready Vegan Capsules Produced in USA

The NatureSpan® Difference

🧬 Foundational 400 mcg 5-MTHF

A right-sized daily dose for ongoing maintenance; easy to pair with multivitamins or diet without overshooting total intake.

🧬 Quatrefolic® Active Folate

Bioactive (6S)-5-MTHF glucosamine salt for consistent uptake—even with common MTHFR variants—for dependable folate status.

🧬 Methylation & Heart Balance

Supports one-carbon metabolism to help regulate homocysteine and sustain cardiovascular and cognitive wellness.

🧬 Gentle, Everyday Compliance

Vegan, non-GMO, allergen-conscious capsule designed for long-term use and routine nutritional coverage.

Supplement Facts

NatureSpan® Folate 5-Methyltetrahydrofolic Acid 400 mcg

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Folate

(as Quatrefolic® [glucosamine salt of (6S)-5-methyltetrahydrofolic])

680 mcg DFE

170%

Other Ingredients: Rice flour, hypromellose (vegetable capsule), magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis by Lesaffre.

Quatrefolic® folate is the result of Gnosis by Lesaffre's research on folate derivatives and is the only company whose three folate products have been granted GRAS (Generally Recognized As Safe) status.

In 2011, Quatrefolic® received the Nutritional Food Business Technology Award (NBT), being recognized as "the most effective strategic product R&D."

Quatrefolic® won the NutrAward in 2012, being rated as "the best and latest in nutrition."

Quatrefolic® patent number: US 7,947,662 B2

Usage & Safety

Who It’s For: Adults seeking daily folate support for healthy methylation, homocysteine metabolism, cellular energy, and prenatal/nervous system health. Suitable for those who prefer the active form of folate (5-MTHF), including individuals who may not efficiently convert synthetic folic acid.*

Who Should Avoid It: Not recommended without physician guidance if you are pregnant/nursing, under 18, have a medical condition, or take medications—especially antifolate therapies (e.g., methotrexate or certain chemotherapeutics), anticonvulsants, or if you have vitamin B12 deficiency (high folate may mask B12 deficiency). Discontinue and consult a professional if you experience adverse effects.*

Dosage: Take 1 capsule daily with a meal, or as directed by your healthcare professional. Each capsule provides 400 mcg of 5-methyltetrahydrofolate (5-MTHF).*

Bottle Supply: 60 veggie capsules (60-day supply at 1 capsule daily).*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility for quality and safety.*

Scientific References

Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5-methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:312-319. PMID: 32868164.
Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Am J Med Sci. 2017 Oct;354(4):379-387. PMID: 29078842.
Sicińska E, Brzozowska A, Roszkowski W, Finglas PM. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Int J Food Sci Nutr. 2018 Feb;69(1):64-73. PMID: 28460586.
Norsworthy B, Skeaff CM, Adank C, Green TJ. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004 Mar;58(3):548-54. PMID: 14985695.

Heart & Prenatal Health Folate 5-Methyltetrahydrofolic Acid 400 mcg

$49.99

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Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Gentle, Daily Bioactive Folate Support

Right-sized 400 mcg Quatrefolic® 5-MTHF delivers ready-to-use folate for methylation, homocysteine balance, and prenatal neural tube support. MTHFR-friendly, vegan capsules provide reliable, gentle daily coverage.

Right-Sized 400 mcg Dose

Designed as a foundational daily folate, this strength supports maintenance needs and pairs easily with a multivitamin or prenatal, helping you personalize total folate intake.

Quatrefolic® Absorption Advantage

Fourth-generation, bioactive 5-MTHF skips conversion steps for consistent absorption. Ideal for those seeking reliable folate status across varied genetics and life stages.

Methylation & Homocysteine Support

Provides the usable folate that powers one-carbon metabolism to help regulate homocysteine—supporting cardiovascular health, neurotransmitter production, and energy.

Gentle, Vegan & Stackable

Vegan, non-GMO, allergen-conscious capsules are easy on routine use. The flexible 400 mcg format makes it simple to adjust or stack with diet and physician-guided protocols.

FAQ

What makes 400 mcg of folate a good choice?

The 400 mcg strength is often recommended for daily maintenance of folate levels. It’s a gentle yet effective dose that supports energy, mood balance, and healthy cell function without being overwhelming.

How does this form of folate compare to folic acid in food or other supplements?

This supplement uses 5-Methyltetrahydrofolic Acid (5-MTHF) — the biologically active form of folate. Unlike folic acid, it’s ready for your body to absorb and use right away, which is especially helpful for people who may not efficiently convert folic acid.

Is this product only for women, or can men take it too?

While folate is well-known for its role in women’s reproductive health, it’s also essential for men and older adults. It helps maintain cardiovascular health, supports brain function, and aids in DNA repair, which are important for everyone.

Can I take this supplement long-term?

Yes. Folate is a water-soluble B vitamin, which means your body uses what it needs and naturally eliminates the rest. Taken as directed, it’s safe for daily use to help support lifelong wellness.