A bottle of Nature Span® Folate 5-Methyltetrahydrofolic Acid 400 mcg supplements, with a white label and orange and white branding.

The backside of a bottle of Nature Span® Folate 5-Methyltetrahydrofolic Acid 400 mcg supplements, with a white label and orange and white branding.

The supplement facts of Nature Span® Folate 5-Methyltetrahydrofolic Acid 400 mcg supplements, with a white label and orange and white branding.

Folate [6S]-5-Methyltetrahydrofolic Acid 400 mcg

$49.99

4.1

Quantity:

Bottle Size: 30 Veggie Capsules

30 Veggie Capsules

Key Benefits

✔ Supports prenatal neural tube development
✔ Maintains healthy homocysteine & cardiovascular function
✔ Promotes red blood cell formation & energy metabolism
✔ Supports methylation & neurotransmitter pathways
✔ Delivers gentle, foundational daily folate support

Quatrefolic® (6S)-5-MTHF Methylation Ready Vegan Capsules Produced in USA

The NatureSpan® Difference

🧬 Foundational 400 mcg (6S)-5-MTHF

A right-sized daily dose for ongoing maintenance; easy to pair with multivitamins or diet without overshooting total intake.

🧬 Quatrefolic® Active Folate

Bioactive (6S)-5-MTHF glucosamine salt for consistent uptake—even with common MTHFR variants—for dependable folate status.

🧬 Methylation & Heart Balance

Supports one-carbon metabolism to help regulate homocysteine and sustain cardiovascular and cognitive wellness.

🧬 Gentle, Everyday Compliance

Vegan, allergen-conscious capsule designed for long-term use and routine nutritional coverage.

Supplement Facts

Nature Span® Folate 5-Methyltetrahydrofolic Acid 400 mcg

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Folate

(as Quatrefolic® [glucosamine salt of (6S)-5-methyltetrahydrofolic])

680 mcg DFE

170%

Other Ingredients: Rice flour, hypromellose (vegetable capsule), magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis by Lesaffre.

Quatrefolic® folate is the result of Gnosis by Lesaffre's research on folate derivatives and is the only company whose three folate products have been granted GRAS (Generally Recognized As Safe) status.

In 2011, Quatrefolic® received the Nutritional Food Business Technology Award (NBT), being recognized as "the most effective strategic product R&D."

Quatrefolic® won the NutrAward in 2012, being rated as "the best and latest in nutrition."

Quatrefolic® patent number: US 7,947,662 B2

Usage & Safety

Who It’s For: Ideal for couples planning for pregnancy, pregnant women, individuals with elevated homocysteine levels, those with hypertension, and adults seeking cellular and cardiovascular health support.*

Who Should Avoid It: Not recommended for individuals taking medications or with underlying health concerns without first consulting a healthcare provider.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 30 capsules (1-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in an FDA, NSF-certified GMP facility. Allergen-free, vegan, and formulated with Quatrefolic® for superior absorption and purity.*

Scientific References

Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5-methyl tetrahydrofolate supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:312-319. PMID: 32868164.
Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL. Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease. Am J Med Sci. 2017 Oct;354(4):379-387. PMID: 29078842.
Sicińska E, Brzozowska A, Roszkowski W, Finglas PM. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Int J Food Sci Nutr. 2018 Feb;69(1):64-73. PMID: 28460586.
Norsworthy B, Skeaff CM, Adank C, Green TJ. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004 Mar;58(3):548-54. PMID: 14985695.

Heart & Prenatal Health Folate [6S]-5-Methyltetrahydrofolic Acid 400 mcg

$49.99

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100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Gentle, Daily Bioactive Folate Support

Right-sized 400 mcg Quatrefolic® (6S)-5-MTHF delivers ready-to-use folate for methylation, homocysteine balance, and prenatal neural tube support. MTHFR-friendly, vegan capsules provide reliable, gentle daily coverage.

Right-Sized 400 mcg Dose

Designed as a foundational daily folate, this strength supports maintenance needs and pairs easily with a multivitamin or prenatal, helping you personalize total folate intake.

Quatrefolic® Absorption Advantage

Fourth-generation, bioactive (6S)-5-MTHF skips conversion steps for consistent absorption. Ideal for those seeking reliable folate status across varied genetics and life stages.

Methylation & Homocysteine Support

Provides the usable folate that powers one-carbon metabolism to help regulate homocysteine—supporting cardiovascular health, neurotransmitter production, and energy.

Gentle, Vegan & Stackable

Vegan, allergen-conscious capsules are easy on routine use. The flexible 400 mcg format makes it simple to adjust or stack with diet and physician-guided protocols.

FAQ

What makes 400 mcg of folate a good choice?

The 400 mcg strength is thoughtfully balanced for daily nutritional maintenance. It’s a gentle yet effective dose that supports natural energy and cellular wellness.

How does this form of folate compare to folic acid in food or other supplements?

This supplement provides 5-Methyltetrahydrofolic Acid (5-MTHF) — the bioactive form of folate that’s readily available for absorption and use, offering dependable folate support for daily nutrition.

Is this product only for women, or can men take it too?

Folate is an essential nutrient for both men and women at all life stages. It supports normal cellular processes, contributes to energy metabolism, and plays a role in maintaining overall wellbeing.

Can I take this supplement long-term?

Yes. Folate is a water-soluble B vitamin, which means your body uses what it needs and naturally eliminates the rest. Taken as directed, it’s safe for daily use to help support lifelong wellness.

I’ve been taking the Folate [6S]-5-Methyltetrahydrofolic Acid 400 mcg supplement for several weeks now and I’m genuinely impressed. The active 6S form absorbs easily and doesn’t upset my stomach the way some folic acid products do. I feel more energized, my mood is steadier, and I appreciate knowing I’m getting a high-quality, science-backed form of folate. The capsules are small, easy to swallow, and come in secure packaging. Highly recommend this product to anyone looking for a reliable folate supplement!

Exactly the right daily dose

Simple, effective, and no side effects. I like that it’s not too strong.

Steady results

I’ve been on Folate 400 for about two months now. It’s not a dramatic difference, but I notice I’m less sluggish in the mornings and don’t crash mid-afternoon like before. Packaging was solid, shipping quick, and the capsules are easy to swallow. Honestly, I’m glad I tried it—subtle changes but they add up.

Gentle supplement

This is one of the only vitamins that doesn’t upset my stomach. The 400 mcg is mild but effective. Took about 3 weeks to feel anything, but now I just feel more balanced overall.

Subtle but noticeable

At first I wasn’t sure if it was doing anything. But after a month, I realized I was sleeping better and not as moody. Small changes, but real ones.

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