A bottle of NatureSpan® Bioactive B100 + Patented PQQ dietary supplement.

Bioactive B100 + Patented PQQ

Q: How does PQQ add extra benefits?

Think of PQQ as your cell’s personal trainer. It helps your body grow new mitochondria (your cell’s “powerhouses”), so you don’t just feel an energy boost — you’re literally upgrading your body’s energy factories at the source.

Q: Who is this product best suited for?

Great question! It’s perfect for anyone who feels low on energy, mentally drained, or under daily stress . Whether you’re juggling work, workouts, or just want to keep aging cells happy, this combo supports body and mind at every stage.

$59.99

Quantity:

Bottle Size: 60 Capsules

60 Capsules

Key Benefits

✔ Elevates cellular energy and daily vitality*
✔ Supports cognitive function and mental clarity*
✔ Promotes healthy stress resilience and restful sleep*
✔ Maintains healthy metabolism and nutrient utilization*
✔ Supports reproductive wellness and red blood cell formation*

Bioactive B-Complex PurQQ® PQQ Quatrefolic® 5-MTHF Produced in USA

The NatureSpan® Difference

🛡️ PurQQ® PQQ Mitochondrial Power

FDA GRAS-confirmed PQQ supports mitochondrial biogenesis and antioxidant defense, complementing B-vitamins for sustained cellular energy.

🛡️ Quatrefolic® Active Folate

Bioavailable 5-MTHF bypasses common conversion steps to support methylation, homocysteine balance, and healthy red blood cell formation.

🛡️ Fully Bioactive B-Complex

Methylcobalamin B12, riboflavin-5′-phosphate, and P-5-P B6 arrive ready to use, supporting neurotransmitters, stress response, and energy metabolism.

🛡️ Clean, High-Potency Formula

Vegan capsules with supportive choline and inositol; non-GMO and allergen-conscious, crafted to rigorous GMP/NSF standards.

Supplement Facts

NatureSpan® Bioactive B100 + Patented PQQ

Supplement Facts

Serving Size: 2 Vegetarian Capsules

Servings Per Container: 30

Amount Per Serving

%DV

Vitamin B1

(as Thiamine HCl)

100 mg

8333%

Vitamin B2

(as Riboflavin-5-Phosphate)

100 mg

7692%

Vitamin B3

(from 125 mg of Inositol Hexanicotinate)

100 mg

625%

Inositol

(from 125 mg of Inositol Hexanicotinate)

40 mg

†

Vitamin B6

(as Pyridoxine HCl, Pyridoxal-5-Phosphate)

100 mg

5882%

Folate

(from Quatrefolic®, (6S)-5-Methyltetrahydrofolate Glucosamine Salt)

680 mcg DFE

170%

Vitamin B12

(as Methylcobalamin)

300 mcg

12501%

Biotin

1 mg

3332%

Vitamin B5

(from d-Calcium Pantothenate)

230 mg

4600%

Calcium

(from d-Calcium Pantothenate)

20 mg

2%

Choline

(from L-Choline Bitartrate)

100 mg

20%

Pyrroloquinoline Quinone Disodium Salt (PQQ)

(as PureQQ®)

1 mg

†

† Daily Value not established.

Daily value for adults based on 2000 calories per day.

Other Ingredients: HPMC (capsule), silica, magnesium stearate (vegetable source).

PurQQ® Patent Numbers: US 8,088,422 B2, ZL 20121 0452297.6, ZL200810033088.1

PurQQ® is a registered trademark of HOWTIAN LLC, the producer of PureQQ® pyrroloquinoline quinone products and the representative for the global market.

PurQQ® is the only PQQ confirmed as Generally Recognized As Safe (GRAS) by the US FDA

Quatrefolic® is a registered trademark of Gnosis by Lesaffre.

Quatrefolic® tetrahydrofolate is a research result of folic acid derivatives by Gnosis by Lesaffre, the only company recognized with GRAS status for all three types of folate products.

In 2011, Quatrefolic® received the Nutrition Business Technology (NBT) award, being acknowledged as "the most effective strategic product R&D."

Quatrefolic® was awarded the NutrAward in 2012, recognized as "the best and latest in nutrition."

Quatrefolic® Patent Number: US 7,947,662 B2

Usage & Safety

Who It’s For: Ideal for individuals seeking to boost energy, improve sleep quality, support brain health, enhance stress resistance, optimize reproductive health, and maintain healthy blood and metabolism.*

Who Should Avoid It: Not recommended for individuals taking medications or those with specific health conditions without consulting a physician.*

Dosage: Take 2 capsules daily with a meal.*

Bottle Supply: 60 veggie capsules (1-month supply).*

Certified Quality: Manufactured in an FDA-registered, GMP and NSF-certified facility; free from the eight major allergens for safety and purity.*

Scientific References

Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A. Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients. 2020 Jan 16;12(1):228. doi: 10.3390/nu12010228. PMID: 31963141; PMCID: PMC7019700.
Vilches-Flores A, Fernández-Mejía C. Efecto de la biotina sobre la expresión genética y el metabolismo [Effect of biotin upon gene expression and metabolism]. Rev Invest Clin. 2005 Sep-Oct;57(5):716-24. Spanish. PMID: 16419467.
Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr. 2006;26:229-50. doi: 10.1146/annurev.nutr.26.061505.111156. PMID: 16848706; PMCID: PMC2441939.
Koury MJ, Ponka P. New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr. 2004;24:105-31. doi: 10.1146/annurev.nutr.24.012003.132306. PMID: 15189115.
Tamakoshi M, Suzuki T, Nishihara E, Nakamura S, Ikemoto K. Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults. Food Funct. 2023 Mar 6;14(5):2496-2501. doi: 10.1039/d2fo01515c. PMID: 36807425.
Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EM. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z. PMID: 36703143; PMCID: PMC9878965.

Brain & Metabolic Health Bioactive B100 + Patented PQQ

$59.99

Fast Delivery for Your Family

We make sure wellness reaches your home without delay. Read more about our shipping policy

100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

Bioactive Energy, Brain & Balance

Bioactive B-complex with Quatrefolic® 5-MTHF and PurQQ® PQQ powers mitochondria, supports methylation and brain function, and promotes healthy stress resilience. Methyl B12, R-5-P & P-5-P deliver effective daily support in vegan capsules.

Patented PurQQ® PQQ

Backed by FDA GRAS status, PQQ supports mitochondrial biogenesis and antioxidant defenses. In synergy with B-vitamins, it helps elevate energy, focus, and day-to-day stamina.

Quatrefolic® 5-MTHF Folate

Active folate form bypasses common conversion steps for reliable uptake. Supports methylation pathways, homocysteine balance, and healthy red blood cell formation.

Methylated, Coenzyme Bs

Methylcobalamin B12, riboflavin-5′-phosphate, and P-5-P B6 arrive ready for use. They aid neurotransmitter synthesis, stress response, and efficient energy metabolism.

Comprehensive Daily Support

Includes choline and inositol to support membrane integrity and nerve health. Clean, vegan, allergen-conscious formula designed for sustained metabolic and cognitive performance.

FAQ

What makes this formula different from a regular B-complex?

Most B vitamins on the market use basic forms that your body has to convert before use. Ours are bioactive, meaning they’re already in the form your body loves — ready to support energy, focus, and metabolism without extra steps.

How does PQQ add extra benefits?

Think of PQQ as your cell’s personal trainer. It helps your body grow new mitochondria (your cell’s “powerhouses”), so you don’t just feel an energy boost — you’re literally upgrading your body’s energy factories at the source.

Will this give me a jittery energy like coffee?

Nope. This isn’t a quick caffeine rush. Instead, it supports steady, natural energy by improving how your cells use fuel. Most people describe it as feeling clear-headed, focused, and energized without the crash.

Who is this product best suited for?

Great question! It’s perfect for anyone who feels low on energy, mentally drained, or under daily stress. Whether you’re juggling work, workouts, or just want to keep aging cells happy, this combo supports body and mind at every stage.

Bioactive B100 + Patented PQQ

Key Benefits

The NatureSpan® Difference

We make sure wellness reaches your home without delay. Read more about our shipping policy

Shop with confidence, backed by our 30-day return policy.

Backed by science, crafted with patented ingredients. Read more about our standard.

FAQ

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