A box of Nature Span® Tri-Layer Tablets Activated Homocysteine with red and white color scheme.

Activated Homocysteine

$59.99

4.0

Quantity:

Bottle Size: 60 Veggie Capsules

60 Veggie Capsules

Key Benefits

✔ Supports healthy homocysteine metabolism for balanced wellness and energy
✔ Promotes natural methylation processes to sustain vitality and mental focus
✔ Helps maintain normal liver function and lipid metabolism with betaine (TMG)
✔ Supports red blood cells & nerve health with active B-vitamins
✔ Delivers bioactive 5-MTHF for cell renewal & DNA synthesis

Quatrefolic® (6S)-5-MTHF Methyl B12 + P5P TMG Synergy Produced in USA

The Nature Span® Difference

🧬 Quatrefolic® (6S)-5-MTHF

Bioactive folate form designed for efficient absorption and consistent folate utilization to support metabolic balance.

🧬 Methylated & Coenzyme B’s

Methylcobalamin (B12) and pyridoxal-5-phosphate (B6) arrive in body-ready forms for dependable absorption and effective nutrient activity.

🧬 TMG (Betaine) Synergy

Natural methyl donor that complements folate and B12 pathways, supporting balanced homocysteine and healthy metabolic processes.

🧬 Clinical-Dose, Clean Label

Thoughtful, evidence-led formulation in vegan capsules; gluten-free, and soy-free for everyday confidence.

Supplement Facts

Nature Span® Activated Homocysteine

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 60

Amount Per Serving

%DV

Vitamin B6

(as pyridoxal 5-phosphate)

50 mg

2,941%

Folate

(as Quatrefolic® [6S]-5-methyltetrahydrofolic acid equivalent to 1.6 mg of [6S]-5-methyltetrahydrofolic acid, glucosamine salt)

800 mcg DFE

200%

Vitamin B12

(methylcobalamin)

500 mcg

20,833%

TMG

(trimethylglycine from betaine anhydrous)

500 mg

†

† Daily Value not established.

Other Ingredients: Hypromellose (vegetable capsule), rice flour, magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis S.p.A., U.S. patent no. 7,947,622.

Usage & Safety

Who It’s For: Ideal for individuals looking to support cardiovascular and cerebrovascular health, maintain healthy cholesterol and homocysteine levels, protect liver function, enhance neurological and cognitive health, and promote overall vitality.*

Who Should Avoid It: Not recommended for individuals taking medications or those with medical conditions without consulting a physician.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 60 capsules (2-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in an FDA, Eurofins certified GMP facility, free from the major common allergens for safety and purity.*

Scientific References

Friso S, Lotto V, Corrocher R, Choi SW. Vitamin B6 and cardiovascular disease. Subcell Biochem. 2012;56:265-90.
Cui Q, Zhu X, Guan G, Hui R, Zhu L, Wang J, Zhao J. Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults. Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1225-1234.
Kliueva NN, Kalashnikova NM, Okunevich IV, Sapronov NS. [Hypolipidemic activity of trimethylglycine]. Eksp Klin Farmakol. 2012;75(1):16-8. Russian.
Miraglia N, Dehay E. Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate. Altern Ther Health Med. 2022 May;28(4):12-17. PMID: 35653630.
Ryan-Harshman M, Aldoori W. Vitamin B12 and health. Can Fam Physician. 2008 Apr;54(4):536-41. PMID: 18411381; PMCID: PMC2294088.

Cardiovascular & Brain Health Activated Homocysteine

$59.99

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Activated Homocysteine & Methylation Support

Quatrefolic® 5-MTHF, methylcobalamin B12, and P5P B6 combine with betaine (TMG) to support homocysteine metabolism, balanced methylation, and cellular energy—delivered in clean, vegan capsules.

Bioactive Quatrefolic® Folate

Utilizes research-backed (6S)-5-MTHF to enter the methylation cycle efficiently. Supports homocysteine conversion, cellular health, and DNA synthesis for foundational wellness.

Methyl B12 + P5P B6

Provides active nutrient forms that assist energy metabolism and red blood cell formation. Designed for efficient absorption and balanced homocysteine management.

Betaine-Driven Synergy

TMG acts as a natural methyl donor, complementing folate and B12 activity. Together they help maintain balanced homocysteine levels and support healthy metabolic and liver function for whole-body vitality.

Clean, Consistent Formulation

Vegan capsules with transparent dosing and quality standards. Gluten-free and soy-free to fit modern lifestyles without compromising effectiveness.

FAQ

What does “Activated Homocysteine” mean?

This formula is designed to help maintain homocysteine within a healthy range by using active forms of B-vitamins and other key nutrients. “Activated” simply means your body can use the nutrients efficiently, supporting natural metabolic balance.

Why are healthy homocysteine levels important?

Balanced homocysteine supports overall cellular metabolism and general wellness. Keeping homocysteine in a normal range helps sustain energy production and daily vitality.

Who might benefit from taking Activated Homocysteine?

It’s designed for adults seeking to support energy, focus, and daily metabolic balance. It can also provide additional nutritional support for long-term wellness and vitality.

How is this product different from a standard B-complex?

Unlike standard formulas, this supplement uses advanced, bioavailable forms such as methylated B12 and folate. That means more efficient absorption and dependable daily nutritional support.

Impressed

I’ve struggled with elevated homocysteine for years and tried a lot of supplements. After about 8 weeks on this, my last blood test showed a good drop. I like that there’s no jitteriness or weird side effects. Feels like my body is finally catching up.

Finally something that makes sense

I’ve been tracking my homocysteine levels for years. After using this for about 8 weeks, my latest lab showed a meaningful drop. No weird side effects. I feel steadier and less “off.” This is a keeper.

Not really sure yet

I wanted this to be a game changer, but after ~5 weeks I’m not sure it is. I don’t feel worse, but I don’t feel much better either. I’ll continue and test labs before judging.

Works quietly but effectively

This one is subtle — you don’t “feel” it like a stimulant, but over a few weeks things just smooth out. No peaks or crashes. For me, that consistency is what matters.

Solid support, hope labs agree

It’s too early to be dramatic, but I can feel subtle things: less brain fog, less fatigue late in the day. The capsule is gentle. I’m waiting on next lab results to see actual numbers, but so far I’m pleased.

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