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The supplement facts of Nature Span® Tri-Layer Tablets Activated Homocysteine with red and white color scheme.

Activated B-Complex for Methylation Support

Energy & Cognitive Support

Activated B-Complex for Methylation Support

$59.99

4.0

Quantity:

Bottle Size: 60 Veggie Capsules

60 Veggie Capsules

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Key Benefits

✔ Supports healthy methylation pathways for everyday wellness and energy*
✔ Promotes efficient nutrient metabolism to sustain vitality and mental focus*
✔ Helps maintain normal liver function and metabolic balance with betaine (TMG)*
✔ Supports red blood cell formation and nerve health with active B-vitamins*
✔ Delivers bioactive 5-MTHF to support cellular renewal and DNA synthesis*

Quatrefolic® (6S)-5-MTHF Methyl B12 + P5P TMG Synergy Produced in USA

The Nature Span® Difference

🧬 Quatrefolic® (6S)-5-MTHF

Bioactive folate form designed for efficient absorption and consistent utilization to support methylation and overall metabolic balance*

🧬 Methylated & Coenzyme B’s

Methylcobalamin (B12) and pyridoxal-5-phosphate (B6) are provided in body-ready forms to support nutrient activity and energy metabolism*

🧬 TMG (Betaine) Synergy

A natural methyl donor that complements folate and B-vitamin pathways, supporting balanced metabolic processes*

🧬 Clean-Label, Thoughtful Formulation

Evidence-led formulation in vegan capsules; gluten-free and soy-free for confident everyday nutritional support*

Supplement Facts

Nature Span® Activated Homocysteine

Supplement Facts

Serving Size: 1 Vegetarian Capsule

Servings Per Container: 60

Amount Per Serving

%DV

Vitamin B6

(as pyridoxal 5-phosphate)

50 mg

2,941%

Folate

(as Quatrefolic® [6S]-5-methyltetrahydrofolic acid equivalent to 1.6 mg of [6S]-5-methyltetrahydrofolic acid, glucosamine salt)

800 mcg DFE

200%

Vitamin B12

(methylcobalamin)

500 mcg

20,833%

TMG

(trimethylglycine from betaine anhydrous)

500 mg

†

† Daily Value not established.

Other Ingredients: Hypromellose (vegetable capsule), rice flour, magnesium stearate, silicon dioxide.

Quatrefolic® is a registered trademark of Gnosis S.p.A., U.S. patent no. 7,947,622.

Usage & Safety

Who It’s For: Ideal for individuals looking to support cardiovascular and cerebrovascular health, maintain healthy cholesterol and homocysteine levels, protect liver function, enhance neurological and cognitive health, and promote overall vitality.*

Who Should Avoid It: Not recommended for individuals taking medications or those with medical conditions without consulting a physician.*

Dosage: Take 1 capsule daily with a meal.*

Bottle Supply: 60 capsules (2-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in an FDA, Eurofins certified GMP facility, free from the major common allergens for safety and purity.*

Scientific References

Friso S, Lotto V, Corrocher R, Choi SW. Vitamin B6 and cardiovascular disease. Subcell Biochem. 2012;56:265-90.
Cui Q, Zhu X, Guan G, Hui R, Zhu L, Wang J, Zhao J. Associations of vitamin B6 turnover rate with the risk of cardiovascular and all-cause mortality in hypertensive adults. Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1225-1234.
Kliueva NN, Kalashnikova NM, Okunevich IV, Sapronov NS. [Hypolipidemic activity of trimethylglycine]. Eksp Klin Farmakol. 2012;75(1):16-8. Russian.
Miraglia N, Dehay E. Folate Supplementation in Fertility and Pregnancy: The Advantages of (6S)5-Methyltetrahydrofolate. Altern Ther Health Med. 2022 May;28(4):12-17. PMID: 35653630.
Ryan-Harshman M, Aldoori W. Vitamin B12 and health. Can Fam Physician. 2008 Apr;54(4):536-41. PMID: 18411381; PMCID: PMC2294088.

Energy & Cognitive Support Activated B-Complex for Methylation Support

$59.99

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Activated Homocysteine & Methylation Support

Quatrefolic® 5-MTHF, methylcobalamin B12, and P5P B6 combine with betaine (TMG) to support homocysteine metabolism, balanced methylation, and cellular energy—delivered in clean, vegan capsules.

Bioactive Quatrefolic® Folate

Utilizes research-backed (6S)-5-MTHF to support efficient entry into normal methylation pathways. This bioactive folate form helps support cellular renewal, DNA synthesis, and overall metabolic balance as part of foundational daily wellness.*

Methyl B12 + P5P B6

Provides body-ready forms of vitamin B12 and vitamin B6 that support energy metabolism, red blood cell formation, and nervous system health. These active nutrient forms are selected for efficient absorption and reliable daily nutritional support.*

Betaine-Driven Synergy

TMG acts as a natural methyl donor that complements folate and B-vitamin pathways. Together, these nutrients support balanced metabolic processes and normal nutrient utilization to promote whole-body vitality.*

Clean, Consistent Formulation

Vegan capsules with transparent dosing and quality standards. Gluten-free and soy-free, designed to fit modern lifestyles while providing dependable everyday nutritional support.*

FAQ

What does “Activated” mean in this formula?

This formula uses active, bioavailable forms of B-vitamins that are ready for your body to use. “Activated” refers to nutrient forms such as methylated B12 and active folate, which support efficient nutrient utilization and normal metabolic processes as part of a healthy lifestyle.

Why is methylation support important?

Methylation is a natural biochemical process involved in energy production, cellular renewal, and nutrient metabolism. Supporting healthy methylation pathways helps the body efficiently process nutrients and maintain everyday vitality.

Who may benefit from this formula?

This product is designed for adults seeking nutritional support for energy, focus, and metabolic balance. It provides bioavailable B-vitamins to support daily wellness and long-term nutritional needs.

How is this product different from a standard B-complex?

Unlike standard formulas, this supplement uses advanced, bioavailable forms such as methylated B12 and folate. That means more efficient absorption and dependable daily nutritional support.