A box of Nature Span® probiotic supplement with the text '30 Billion CFU 16-Strain Probiotic with FOS' displayed on the front.

The supplement facts of Nature Span® probiotic supplement with the text '30 Billion CFU 16-Strain Probiotic with FOS' displayed on the front.

30 Billion CFU 16-Strain Probiotics

$59.99

4.4

Quantity:

Box Size: 30 Delayed-Release Veggie Capsules

30 Delayed-Release Veggie Capsules

Key Benefits

✔ Supports digestive comfort and regularity
✔ Helps restore microbiome balance after routine changes
✔ Supports normal lactose digestion
✔ Promotes gut barrier integrity and balanced defense function
✔ Contributes to daily vitality and overall wellbeing

No Refrigeration DR-Vegan Capsules Blister Sealed Produced in USA

The Nature Span® Difference

🛡️ DuPont Clinical Strains

Includes La-14™ and Lc-11™, with data supporting their stability and performance in humans; additional research highlights their roles in promoting balanced digestive function and overall wellness.

🛡️ 16-Strain, 30 Billion Spectrum

Balanced Lactobacillus and Bifidobacterium blend delivers broad coverage across the GI tract for a diverse, resilient microbiota.

🛡️ Delayed-Release Vegan Capsules

Acid-resistant technology helps live cultures survive stomach acid for targeted intestinal delivery—no refrigeration required.

🛡️ Synbiotic & Shelf-Stable

FOS prebiotics nourish beneficial bacteria; dual-foil blister sealing protects against heat, moisture, and oxygen to preserve potency and freshness.

Supplement Facts

Nature Span® 30 Billion CFU 16-Strain Probiotics

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

Amount Per Serving

%DV

Probiotic Bacteria Blend

Total Cultures

274 mg30 Billion CFU

†

Lactobacillus acidophilus (La-14)

6.5 Billion CFU

†

Lactobacillus reuteri

1.5 Billion CFU

†

Lactobacillus helveticus

500 Million CFU

†

Lactobacillus rhamnosus (Lr-32)

3 Billion CFU

†

Lactococcus lactis

8 Billion CFU

†

Lactobacillus brevis

1.5 Billion CFU

†

Bifidobacterium bifidum

1 Billion CFU

†

Lactobacillus bulgaricus

325 Million CFU

†

Bifidobacterium lactis (Bl-04)

2.5 Billion CFU

†

Lactobacillus plantarum (Lp-115)

2 Billion CFU

†

Bifidobacterium longum (Bl-05)

500 Million CFU

†

Streptococcus thermophilus

1 Billion CFU

†

Bifidobacterium infantis

500 Million CFU

†

Lactobacillus salivarius (Ls-33)

500 Million CFU

†

Bifidobacterium breve (Bb-03)

500 Million CFU

†

Lactobacillus casei (Lc-11)

500 Million CFU

†

Fructooligosaccharide (FOS)

100 mg

†

† Daily Value not established.

Other Ingredients: Delayed-release vegetarian capsule (hypromellose, gellan gum), magnesium stearate, microcrystalline cellulose, inulin, and silicon dioxide (silica).

All strains are supplied by DuPont, a Fortune 500 company established in 1802.

Clinically researched strain La-14™.

Clinically researched strain Lc-11™.

Usage & Safety

Who It’s For: Ideal for adults seeking daily support for gut balance, relief from occasional constipation, diarrhea, or bloating, improved digestion (including lactose tolerance), enhanced immunity, and overall physical and mental wellness via the gut-brain axis.*

Who Should Avoid It: Not recommended for immunocompromised individuals, critically ill patients, or those taking medications without consulting a physician. Discontinue and seek medical advice if adverse reactions occur.*

Dosage: Take 1 capsule daily with a meal. Delayed-release vegetarian capsule; no refrigeration required.*

Bottle Supply: 30 capsules (1-month supply).*

Best Before: 3 years from MFG date.*

Certified Quality: Manufactured in an FDA, UL and NSF-certified GMP facility; free from the eight major allergens (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy).*

Scientific References

Mohtashami M, Mohamadi M, Azimi-Nezhad M, Saeidi J, Nia FF, Ghasemi A. Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors. Biotechnol Appl Biochem. 2021 Dec;68(6):1421-1431. doi: 10.1002/bab.2064. Epub 2020 Nov 17.
Huang C, Yue Q, Sun L, Di K, Yang D, Hao E, Wang D, Chen Y, Shi L, Zhou R, Zhao G, Chen H. Restorative effects of Lactobacillus rhamnosus LR-32 on the gut microbiota, barrier integrity, and 5-HT metabolism in reducing feather-pecking behavior in laying hens with antibiotic-induced dysbiosis. Front Microbiol. 2023 Apr 26;14:1173804. doi: 10.3389/fmicb.2023.1173804.
Chen S, Han P, Zhang Q, Liu P, Liu J, Zhao L, Guo L, Li J. Lactobacillus brevis alleviates the progress of hepatocellular carcinoma and type 2 diabetes in mice model via interplay of gut microflora, bile acid and NOTCH 1 signaling. Front Immunol. 2023 May 10;14:1179014. doi: 10.3389/fimmu.2023.1179014.
Neville BA, O'Toole PW. Probiotic properties of Lactobacillus salivarius and closely related Lactobacillus species. Future Microbiol. 2010 May;5(5):759-74. doi: 10.2217/fmb.10.35.
Li Y, Li Q, Yuan R, Wang Y, Guo C, Wang L. Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages. Theranostics. 2024 Apr 22;14(7):2719-2735. doi: 10.7150/thno.92350.

Gut Health & Digestive Support 30 Billion CFU 16-Strain Probiotics

$59.99

Fast Delivery for Your Family

We make sure wellness reaches your home without delay. Read more about our shipping policy

100% Satisfaction Guarantee

Shop with confidence, backed by our 30-day return policy.

Premium Quality

Backed by science, crafted with patented ingredients. Read more about our standard.

30 Billion CFU, 16-Strain Daily Gut Support

Clinically supported 16-strain probiotic with 30 Billion CFU to promote microbiome balance, digestive regularity, and everyday wellbeing. DuPont La-14™ & Lc-11™ in delayed-release vegan capsules with FOS prebiotic—blister-sealed for potency, no refrigeration needed.

Clinically Researched DuPont Strains

Features La-14™ and Lc-11™ within a 16-strain complex. Human studies demonstrate strain stability and highlight potential benefits for maintaining balanced gut microbiota and overall wellbeing.

Broad-Spectrum, 30 Billion CFU

Targets both upper and lower GI regions with complementary Lactobacillus and Bifidobacterium species. Promotes digestive comfort, regularity, and diverse microbiota composition.

Delayed-Release, High Survival

Vegetarian, acid-resistant capsules help cultures pass through the stomach and release in the intestines, maximizing viability where they can provide their intended support.

Synbiotic Power & Stability

FOS prebiotics help nourish beneficial bacteria for a thriving gut environment. Dual-foil blister packaging protects against heat, moisture, and oxygen—keeping every capsule fresh and effective.

FAQ

Why 16 strains instead of just a few?

Because your gut is like a rainforest — the more variety, the healthier the ecosystem. Our 16 carefully chosen strains support a wide range of digestive and microbiome functions, encouraging balance across your entire gut community.

Is 30 Billion CFU enough to make a difference?

Yes! It’s an ideal strength for daily digestive support. Too little may not help, too much can be unnecessary. 30 Billion CFU provides robust, balanced probiotic support that’s effective and gentle for everyday use.

Can kids or seniors take this probiotic?

This formula is designed for adults, and many older adults find it beneficial for digestive comfort and microbiome balance. For children, consult a healthcare professional to choose the most appropriate product for their needs.

What’s the best time of day to take it?

Morning, night, or with lunch — it’s flexible!

Many people prefer taking it with their first meal of the day to stay consistent. The key is daily use—find the time that fits your routine and make it a habit.

My gut is happier

Less bloating, better digestion. Works fast for me.

Slow and steady

Not an overnight fix, but I can tell it’s doing something. My stomach feels calmer, and I don’t get those random mid-day crashes as often.

Best probiotic I’ve tried

This is the only probiotic that has really worked for me. Less bloating, better digestion, and I just feel lighter overall. I’ve tried others before, but they were inconsistent. This one is steady and reliable.

Noticeable improvements

Took about three weeks before I saw a difference, but once it kicked in, I realized I wasn’t feeling that heavy “post-meal” discomfort anymore. My digestion feels smoother.

Gentle but effective

I was a little worried about trying something this strong, but honestly it’s been really easy on my system. No cramps, no nausea, just steady improvement. After two weeks, I noticed less gas after meals, especially heavier foods. Very glad I gave it a chance.

30 Billion CFU 16-Strain Probiotics

Key Benefits

The Nature Span® Difference

We make sure wellness reaches your home without delay. Read more about our shipping policy

Shop with confidence, backed by our 30-day return policy.

Backed by science, crafted with patented ingredients. Read more about our standard.

FAQ

Customer Reviews

You may also like